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SRI-29574

CAT: 0804-HY-126158Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-126158Size:1 Each
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Description
SRI-29574 is an allosteric modulator of the dopamine transporter (DAT) . SRI-29574 partially inhibits the uptake of the DAT (IC50=2.3 nM) and also partially inhibits the uptake of the serotonin transporter (SERT) and norepinephrine transporter (NET) . SRI-29574 may serve as a useful probe to study the function and regulatory mechanisms of DAT[1].
CAS Number
1928712-46-2
UNSPSC
12352005
Target
Dopamine Transporter; Serotonin Transporter
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sri-29574.html
Smiles
C1(C2=CN3C(C=C2)=NC=C3)=NC(NCC(C4=CC=CC=C4)C5=CC=CC=C5)=C6C=CC=CC6=N1
Molecular Formula
C29H23N5
Molecular Weight
441.53
References & Citations
[1]Rothman, et al. "Studies of the biogenic amine transporters 15. Identification of novel allosteric dopamine transporter ligands with nanomolar potency." Journal of Pharmacology and Experimental Therapeutics 353.3 (2015) : 529-538.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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