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Selegiline

CAT: 0804-HY-14198-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14198-01Size:5 mg
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Description
Selegiline (Deprenyl) is a potent, selective and irreversible inhibitor of MAO-B, with an IC50 of 51 nM. Selegiline exhibits 450-flod selectivity for MAO-B over MAO-A (IC50=23 μM) . Selegiline can be used for the research of Parkinson's disease, Alzheimer's disease and major depressive disorder[1][2][3].
CAS Number
14611-51-9
Product Name Alternative
Deprenyl; (-) -Selegiline; (-) -Deprenyl
UNSPSC
12352005
Hazard Statement
H302-H312-H332
Target
Monoamine Oxidase
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/selegiline.html
Solubility
10 mM in DMSO
Smiles
CN(CC#C)[C@H](C)CC1=CC=CC=C1
Molecular Formula
C13H17N
Molecular Weight
187.28
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501
References & Citations
[1]Chaurasiya ND, et, al. Selective Inhibition of Human Monoamine Oxidase B by Acacetin 7-Methyl Ether Isolated from Turnera diffusa (Damiana) . Molecules. 2019 Feb 23;24 (4) :810.|[2]Tatton WG, et, al. Modulation of gene expression rather than monoamine oxidase inhibition: (-) -deprenyl-related compounds in controlling neurodegeneration. Neurology. 1996 Dec;47 (6 Suppl 3) :S171-83.|[3]MohanKumar PS, et, al. Deprenyl stimulates the efflux of monoamines from the rat hypothalamus in vitro. Brain Res Bull. 2001 Apr;54 (6) :675-80.|[4]Ho MC, et, al. Chronic treatment with monoamine oxidase-B inhibitors decreases cocaine reward in mice. Psychopharmacology (Berl) . 2009 Jul;205 (1) :141-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
MAO-B
Citation 01
BioRxiv. 2020 Feb.|Head Neck. 2024 Aug;46 (8) :2031-2041.|J Neuroinflammation. 2023 Jul 11;20 (1) :162.|Nutrients. 2023 May 30;15 (11) :2542.|Proc Natl Acad Sci U S A. 2020 Oct 20;117 (42) :26438-26447.|Anal Chem. 2025 Jul 15;97 (27) :14220-14229.|Cell Commun Signal. 2023 Sep 21;21 (1) :250.|Research Square Preprint. 2024 Oct 09.

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