Products for Research Use Only
RegisterLogin

Ub4ix

CAT: 0804-HY-P10714-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-P10714-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Ub4ix is a DUB/26S proteasome inhibitor. Ub4ix can protect K48-linked Ub chains from being chopped up by deubiquitinating enzymes (DUBs) and prevent the proteasomal degradation of Ub-tagged proteins. Ub4ix can reduce the viability of Hela cells and induce apoptosis, with an IC50 value of 1.6 μM[1][2].
CAS Number
2396736-46-0
UNSPSC
12352209
Target
Apoptosis; Deubiquitinase; Proteasome
Type
Peptides
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ub4ix.html
Purity
99.32
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](NC(CSC[C@H](NC([C@](NC1=O)([H])[C@@H](C)CC)=O)C(NCC(N)=O)=O)=O)CC2=CNC3=CC=CC=C23)=O)CC(C)C)=O)CC4=CC=C(C=C4)O)=O)CC(C)C)=O)CC(O)=O)=O)CC(O)=O)=O)CO)=O)=O)CC(O)=O)=O)CC5=CNC6=CC=CC=C56)N[C@H]1CC7=CNC8=CC=CC=C78
Molecular Formula
C84H106N18O23S
Molecular Weight
1767.91
References & Citations
[1]Nawatha M, et al. De novo macrocyclic peptides that specifically modulate Lys48-linked ubiquitin chains. Nat Chem. 2019 Jul;11 (7) :644-652. |[2]Saha A, et al. Combining Chemical Protein Synthesis and Random Nonstandard Peptides Integrated Discovery for Modulating Biological Processes. Acc Chem Res. 2023 Jul 18;56 (14) :1953-1965.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

Alternative Products

CatalogName
CRB1001380-01Ub4ix
CRB1001380-01Ub4ix - (Peptide)

Popular Products