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Ub4ix

CAT: 0931-TP2873-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-TP2873-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2396736-46-0
Target
Proteasome, Apoptosis, DUB
Related Pathways
DNA Damage/DNA Repair, Apoptosis, Ubiquitination, Proteases/Proteasome, Cell Cycle/Checkpoint
Bioactivity
Ub4ix, a DUB/26S proteasome inhibitor, safeguards K48-linked Ub chains against cleavage by deubiquitinating enzymes (DUBs) and inhibits the proteasomal degradation of Ub-tagged proteins. Additionally, it diminishes the viability of Hela cells and triggers apoptosis, exhibiting an IC 50 value of 1.6 μM.
Smiles
C(C=1C=2C(NC1)=CC=CC2)[C@@H]3NC(=O)[C@H](CC=4C=5C(NC4)=CC=CC5)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC6=CC=C(O)C=C6)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC=7C=8C(NC7)=CC=CC8)NC(=O)CSC[C@@H](C(NCC(N)=O)=O)NC(=O)[C@]([C@H](CC)C)(NC3=O)[H]
Molecular Formula
C84H106N18O23S
Molecular Weight
1767.91
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
CRB1001380-01Ub4ix
CRB1001380-01Ub4ix - (Peptide)

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