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GFB-12811

CAT: 0804-HY-144117-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-144117-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GFB-12811 is a high selective CDK5 inhibitor with an IC50 of 2.3 nM[1].
CAS Number
2775311-17-4
UNSPSC
12352005
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/gfb-12811.html
Purity
98.04
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CN1CCC(CC1)[C@@](O)(C2=CC=C3C=NC(NC4=CC(C(F)(F)F)=NC=C4F)=CC3=N2)C
Molecular Formula
C22H23F4N5O
Molecular Weight
449.44
References & Citations
[1]Daniels MH, et al. Discovery and Optimization of Highly Selective Inhibitors of CDK5. J Med Chem. 2022;65 (4) :3575-3596.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK2; CDK5; CDK6; CDK7; CDK9

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