Phospho-Cytosolic Phospholipase A2 (S505) Recombinant Rabbit Monoclonal Antibody [PSH07-16]

Phospho-Cytosolic Phospholipase A2 (S505) Recombinant Rabbit Monoclonal Antibody [PSH07-16]

• Description: Cytosolic phospholipase A2 is an enzyme that in humans is encoded by the PLA2G4A gene. This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca2+ levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.
• Product Name Alternative: Calcium dependent phospholipid binding protein antibody CPLA 2 antibody cPLA2 alpha antibody cPLA2 antibody Cytosolic phospholipase A2 antibody Cytosolic phospholipase A2 group IVA antibody Lysophospholipase antibody MGC126350 antibody PA24A_HUMAN antibody Phosphatidylcholine 2 acylhydrolase antibody Phosphatidylcholine 2-acylhydrolase antibody Phospholipase A2 group 4 A antibody Phospholipase A2 group IVA (cytosolic calcium dependent) antibody Phospholipase A2 group IVA antibody PhospholipaseA2 antibody PLA2G4 antibody pla2g4a antibody
• Abbreviation: PLA2G4A, CPLA2, PLA2G4
• CAS Number: 9000-83-3
• Swiss Prot: P47712 Human, P47713 Mouse
• Cellular Locus: Cytoplasm, Golgi apparatus membrane, Nucleus envelope.
• Host: Rabbit
• Species Reactivity: Human, Mouse
• Immunogen: Synthetic phospho-peptide corresponding to residues surrounding Ser505 of human cPLA2 aa 491-540.
• Isotype: IgG
• Clone: PSH07-16
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB
• Positive Control: HeLa cell lysate, RAW264.7 cell lysates.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 85 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes