Lanatoside C

• Description :

  Lanatoside C is a cardiac glycoside, can be used in the treatment of congestive heart failure and cardiac arrhythmia.Lanatoside C has an IC50 of 0.19 μM for dengue virus infection in HuH-7 cells. Lanatoside C can effectively inhibit all four serotypes of dengue virus, flavivirus Kunjin, alphavirus Chikungunya, Sindbis virus and the human enterovirus 71[1][2].

• UNSPSC :

  12352005

• Hazard Statement :

  H301, H330, H373

• Target :

  Autophagy; CHIKV; Dengue Virus; Enterovirus; Flavivirus

• Type :

  Natural Products

• Related Pathways :

  Anti-infection; Autophagy

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Cardiovascular Disease; Cancer

• Assay Protocol :

  https://www.medchemexpress.com/Lanatoside-C.html

• Purity :

  99.88

• Solubility :

  DMSO : 50 mg/mL (ultrasonic) |Ethanol : 2 mg/mL (ultrasonic)

• Smiles :

  O[C@]([C@@](CC[C@@]1([H])[C@@]2(CC[C@H](O[C@@](O[C@H](C)[C@H]3O[C@@](O[C@H](C)[C@H]4O[C@@](O[C@H](C)[C@H]5O[C@]([C@@H]([C@@H](O)[C@@H]6O)O)([H])O[C@@H]6CO)([H])C[C@@H]5OC(C)=O)([H])C[C@@H]4O)([H])C[C@@H]3O)C1)C)([H])[C@]2([H])C[C@H]7O)(CC[C@@H]8C(CO9)=CC9=O)[C@]78C

• Molecular Formula :

  C49H76O20

• Molecular Weight :

  985.12

• Precautions :

  H301, H330, H373

• References & Citations :

  [1]Crommentuijn MH, et al. Intracranial AAV-sTRAIL combined with lanatoside C prolongs survival in an orthotopic xenograft mouse model of invasive glioblastoma. Mol Oncol. 2015 Dec 11. pii: S1574-7891 (15) 00226-4.|[2]Cheung YY, et al. Antiviral activity of lanatoside C against dengue virus infection. Antiviral Res. 2014 Nov;111:93-99.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  Launched

• CAS Number :

  [17575-22-3]