DNA Gyrase/DHFR-IN-1

• UNSPSC Description:

  DNA Gyrase/DHFR-IN-1 is a dual inhibitor of bacterial DNA gyrase and DHFR, with IC50s of 182 μM and 3.90 μM for E. coli DNA gyrase and DHFR respectively. DNA Gyrase/DHFR-IN-1 has bactericidal and antifungal activity[1].

• Target Antigen:

  Bacterial; Dihydrofolate reductase (DHFR) ; Fungal

• Type:

  Reference compound

• Related Pathways:

  Anti-infection;Metabolic Enzyme/Protease

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/dna-gyrase-dhfr-in-1.html

• Smiles:

  CC1=CC=C(C2=CC(C3=CC=C(OC)C=C3)=NC4=NC(C5=CC=CC=C5)=NN24)C=C1

• Molecular Weight:

  392.45

• References & Citations:

  [1]Lamya H. Al-Wahaibi, et al. Synthesis and Antimicrobial Evaluation of New 1,2,4-Triazolo[1,5-a]pyrimidine-Based Derivatives as Dual Inhibitors of Bacterial DNA Gyrase and DHFR.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported