7-Octynoic acid

7-Octynoic acid

• CAS Number: 10297-09-3
• UNSPSC Description: 7-Octynoic acid (compound 42) is a PROTAC linker and can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. 7-Octynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
• Target Antigen: PROTAC Linkers
• Type: Reference compound
• Related Pathways: PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/7-octynoic-acid.html
• Purity: 98.47
• Solubility: DMSO : 150 mg/mL (ultrasonic)|H2O : 5 mg/mL (ultrasonic)
• Smiles: C#CCCCCCC(O)=O
• Molecular Weight: 140.18
• References & Citations: [1] Bai L, et al. A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo. Cancer Cell. 2019 Nov 11;36(5):498-511.e17.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported