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7-Octynoic acid

CAT: 0804-HY-69220-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-69220-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
7-Octynoic acid (compound 42) is a PROTAC linker and can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. 7-Octynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
10297-09-3
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
PROTAC Linkers
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/7-octynoic-acid.html
Purity
99.53
Solubility
DMSO : 150 mg/mL (ultrasonic) |H2O : 5 mg/mL (ultrasonic)
Smiles
C#CCCCCCC(O)=O
Molecular Formula
C8H12O2
Molecular Weight
140.18
Precautions
H302, H315, H319, H335
References & Citations
[1] Bai L, et al. A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo. Cancer Cell. 2019 Nov 11;36 (5) :498-511.e17.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Alkyl-Chain Linkers

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