Senkyunolide A

• UNSPSC Description:

  Senkyunolide A is a phthalein compound. Senkyunolide A inhibits the proliferation of tumor cells and has anticancer activity. Senkyunolide A inhibits the progression of osteoarthritis through the NLRP3 signaling pathway. Senkyunolide A protects nerve cells from Corticosterone (HY-B1618) -induced apoptosis by regulating protein phosphatase 2A and α-synuclein signaling pathways. Senkyunolide A inhibits the expression of CD137, a diagnostic biomarker for atherosclerosis[1][2][3][4][5].

• Target Antigen:

  Apoptosis; Caspase; Interleukin Related; Lactate Dehydrogenase; NOD-like Receptor (NLR); Phosphatase; α-synuclein

• Type:

  Natural Products

• Related Pathways:

  Apoptosis;Immunology/Inflammation;Metabolic Enzyme/Protease;Neuronal Signaling

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer; Inflammation/Immunology; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/senkyunolide-a.html

• Purity:

  99.92

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C1O[C@@H](CCCC)C2=C1C=CCC2

• Molecular Weight:

  192.258

• References & Citations:

  [1]Kan WL, et al. Study of the anti-proliferative effects and synergy of phthalides from Angelica sinensis on colon cancer cells. J Ethnopharmacol. 2008 Oct 30;120(1):36-43.|[2]Lei W, et al. Phthalides, senkyunolide A and ligustilide, show immunomodulatory effect in improving atherosclerosis, through inhibiting AP-1 and NF-κB expression. Biomed Pharmacother. 2019 Sep;117:109074.|[3]Gong S, et al. Senkyunolide A protects neural cells against corticosterone-induced apoptosis by modulating protein phosphatase 2A and α-synuclein signaling. Drug Des Devel Ther. 2018 Jun 25;12:1865-1879.|[4]Shao M, et al. Senkyunolide A inhibits the progression of osteoarthritis by inhibiting the NLRP3 signalling pathway. Pharm Biol. 2022 Dec;60(1):535-542.|[5]Yan R,et al. Low oral bioavailability and pharmacokinetics of senkyunolide a, a major bioactive component in Rhizoma Chuanxiong, in the rat. Ther Drug Monit. 2007 Feb;29(1):49-56.

• Shipping Conditions:

  Dry Ice

• Storage Conditions:

  -80°C, protect from light, stored under nitrogen

• Clinical Information:

  No Development Reported

• CAS Number:

  63038-10-8