(S,R,S)-AHPC-C5-COOH

(S,R,S)-AHPC-C5-COOH

• CAS Number: 2267282-19-7
• UNSPSC Description: (S,R,S)-AHPC-C5-COOH (VH032-C5-COOH) is a synthesized?E3 ligase ligand-linker conjugate, contains the VH032 VHL-based ligand and a linker to form PROTACs. VH-032 is a selective and potent inhibitor of VHL/HIF-1α interaction with a Kd of 185 nM, has the potential for the study of anemia and ischemic diseases[1].
• Target Antigen: E3 Ligase Ligand-Linker Conjugates; HIF/HIF Prolyl-Hydroxylase
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease;PROTAC
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/s-r-s-ahpc-c5-cooh.html
• Smiles: O=C(N(C[C@H](O)C1)[C@@H]1C(NCC2=CC=C(C(SC=N3)=C3C)C=C2)=O)[C@H](C(C)(C)C)NCCCCCCC(O)=O
• Molecular Weight: 558.73
• References & Citations: [1]Soares P, et al. Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Structure-Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298).J Med Chem. 2018 Jan 25;61(2):599-618.
• Shipping Conditions: Room Temperature