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Taurochenodeoxycholic acid

CAT: 0804-HY-N2027-01Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-N2027-01Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Taurochenodeoxycholic acid (12-Deoxycholyltaurine) is one of the main bioactive substances of animals' bile acid. Taurochenodeoxycholic acid induces apoptosis and shows obvious anti-inflammatory and immune regulation properties[1][2].
CAS Number
516-35-8
Product Name Alternative
12-Deoxycholyltaurine
UNSPSC
12352211
Hazard Statement
H225, H301+H311+H331, H370
Target
Apoptosis; Caspase; Endogenous Metabolite
Type
Natural Products
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Taurochenodeoxycholic_acid.html
Purity
99.90
Solubility
DMSO : ≥ 25 mg/mL|H2O : 100 mg/mL (ultrasonic)
Smiles
C[C@@]1([C@@]2([H])[C@H](C)CCC(NCCS(=O)(O)=O)=O)[C@](CC2)([H])[C@@]([C@@H](C[C@]3([H])C[C@H](O)CC4)O)([H])[C@]([C@]34C)([H])CC1
Molecular Formula
C26H45NO6S
Molecular Weight
499.70
Precautions
H225, H301+H311+H331, H370
References & Citations
[1]Wang X, et al. Taurochenodeoxycholic acid induces NR8383 cells apoptosis via PKC/JNK-dependent pathway. Eur J Pharmacol. 2016 Sep 5;786:109-15.|[2]Zhou C, et al. The effects of taurochenodeoxycholic acid in preventing pulmonary fibrosis in mice. Pak J Pharm Sci. 2013 Jul;26 (4) :761-5.|[3]Uchida A, et al. Taurochenodeoxycholic acid ameliorates and ursodeoxycholic acid exacerbates small intestinal inflammation. Am J Physiol. 1997 May;272 (5 Pt 1) :G1249-57.|[4]Liu M, et al. Effects of taurochenodeoxycholic acid on adjuvant arthritis in rats. Int Immunopharmacol. 2011 Dec;11 (12) :2150-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Launched
Isoform
Human Endogenous Metabolite; Microbial Metabolite
Citation 01
Adv Sci (Weinh) . 2025 Feb 3:e2411719.|Biomedicines. 2025 Apr 4;13 (4) :874.|J Pharm Biomed Anal. 2025 Jul 15:259:116760.|J Transl Med. 2024 Dec 20;22 (1) :1124.|Nat Microbiol. 2023 Jan;8 (1) :91-106.|Nature. 2025 Jul;643 (8070) :192-200.|SSRN. 2022 Jan 26.|Cancer Cell Int. 2025 Apr 22;25 (1) :160.

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