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5HT6-ligand-2

CAT: 0804-HY-162636Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-162636Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
5HT6-ligand-2 (compound 15) is a potent 5-HT6 inhibitor with Ki values of 3.4, 15 nM for 5-HT6, SERT, respectively. 5HT6-ligand-2 shows neuroprotection. 5HT6-ligand-2 has the potential for the research of dementia[1].
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/5ht6-ligand-2.html
Smiles
O=C1N(CC2=CC=CC=C2)C3=CC=CC(N(CC4)CCN4CCC5=CNC6=C5C=C(C#N)C=C6)=C3N1
Molecular Formula
C29H28N6O
Molecular Weight
476.57
References & Citations
[1]Siwek A, et al. Dual 5-HT6/SERT ligands for mitigating neuropsychiatric symptoms of dementia exerting neuroprotection against amyloid-β toxicity, memory preservation, and antidepressant-like properties. Eur J Med Chem. 2024 Sep 5;275:116601.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MUC2

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