Products for Research Use Only
RegisterLogin

Acetazolamide-13C2, d3

CAT: 0804-HY-B0782S1-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-B0782S1-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Acetazolamide-13C2, d3 is the 13C- and deuterium labeled Acetazolamide. Acetazolamide is a carbonic anhydrase (CA) IX inhibitor with an IC50 of 30 nM for hCA IX[1]. Diuretic effects[4].
UNSPSC
12352005
Target
Autophagy; Carbonic Anhydrase; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Autophagy; Metabolic Enzyme/Protease; Others
Applications
Cancer-programmed cell death
Field of Research
Cardiovascular Disease; Cancer
Solubility
10 mM in DMSO
Smiles
O=[13C](NC1=NN=C(S(=O)(N)=O)S1)[13C]([2H])([2H])[2H]
Molecular Formula
C2 13C2H3D3N4O3S2
Molecular Weight
227.25
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-223.|[2]Bayat Mokhtari R, et al. Acetazolamide potentiates the anti-tumor potential of HDACi, MS-275, in neuroblastoma. BMC Cancer. 2017 Feb 24;17 (1) :156.|[3]Gao H, et al. Combined treatment with acetazolamide and cisplatin enhances chemosensitivity in laryngeal carcinoma Hep-2 cells. Oncol Lett. 2018 Jun;15 (6) :9299-9306.|[4]Hou Z, et al. Dual-tail approach to discovery of novel carbonic anhydrase IX inhibitors by simultaneously matching the hydrophobic and hydrophilic halves of the active site. Eur J Med Chem. 2017 May 26;132:1-10.|[5]Kassamali R, et al. Acetazolamide: a forgotten diuretic agent. Cardiol Rev. 2011 Nov-Dec;19 (6) :276-8.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
CA IX

Related Products

CatalogName
HY-B0782S-01Acetazolamide-d3
HY-B0782S2Acetazolamide-15N, d3
HY-90009ASTadalafil-13C2, d3
HY-B0495S6Lamotrigine-13C2,15N2, d3
HY-W766769Cyproterone Acetate-13C2, d3
HY-90009AS1Tadalafil-13C2, d3-1
HY-B0782-01Acetazolamide
HY-16973SFluralaner-13C2,15N, d3
HY-W747168Ethyl Vinyllactate-13C2, d3
HY-17530SAldicarb sulfone-13C2, d3

Alternative Products

CatalogName
AR-A01197-01Acetazolamide-13C2-d3
258732-01Acetazolamide

Popular Products