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SynuClean-D

CAT: 0804-HY-124876-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-124876-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SynuClean-D (SC-D) is an inhibitor of α-synuclein aggregation, disrupts mature amyloid fibrils, prevents fibril propagation, and abolishes the degeneration of dopaminergic neurons in an animal model of Parkinson’s disease[1].
CAS Number
685121-45-3
Product Name Alternative
SC-D
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
α-synuclein
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/synuclean-d.html
Concentration
10mM
Purity
99.89
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
N#CC1=C(C(F)(F)F)C([N+]([O-])=O)=C(C2=CC=CC([N+]([O-])=O)=C2)NC1=O
Molecular Formula
C13H5F3N4O5
Molecular Weight
354.20
Precautions
H302, H315, H319, H335
References & Citations
[1]Pujols J, et al. Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons. Proc Natl Acad Sci U S A. 2018 Oct 9;115 (41) :10481-10486.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
α-synuclein Aggregation

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