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(-) Clausenamide

CAT: 0804-HY-116753-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-116753-01Size:1 mg
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Description
(-) Clausenamide is an active alkaloid isolated from the leaves of Clausena lansium (Lour.) Skeels, and improves cognitive function in both normal physiological and pathological conditions. (-) Clausenamide inhibits β-amyloid (Aβ) toxicity, blocking neurofibrillary tangle formation by inhibiting the phosphorylation of tau protein. (-) Clausenamide exerts a significant neuroprotective activity against Aβ25-35. (-) Clausenamide can be used for researching Alzheimer's disease (AD) [1][2][3].
CAS Number
201529-58-0
Product Name Alternative
Sch 21420 (sulfate)
UNSPSC
12352005
Target
Amyloid-β; Tau Protein
Type
Natural Products
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/minus-clausenamide.html
Purity
99.92
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O[C@@H](C1=CC=CC=C1)[C@@](N2C)([H])[C@](C3=CC=CC=C3)([H])[C@@H](C2=O)O
Molecular Formula
C18H19NO3
Molecular Weight
297.35
References & Citations
[1]Chu S, Liu S, Duan W, et al. The anti-dementia drug candidate, (-) -clausenamide, improves memory impairment through its multi-target effect. Pharmacol Ther. 2016;162:179-187. |[2]Chu SF, Zhang JT. Recent advances in the study of (-) clausenamide: chemistry, biological activities and mechanism of action. Acta Pharm Sin B. 2014;4 (6) :417-423. |[3]Hu JF, et al. Protective effect of (-) clausenamide against Abeta-induced neurotoxicity in differentiated PC12 cells. Neurosci Lett. 2010 Oct 8;483 (1) :78-82.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

Alternative Products

CatalogName
BUP08150-01L-Clausenamide
M39205-01Zeta-Clausenamide

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