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DUB-IN-8

CAT: 0804-HY-163769Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-163769Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DUB-IN-8 (Compound 8q) is an inhibitor for Chlamydia deubiquitinase 1 (DUB1), with IC50 of 7.7 μM. DUB-IN-8 exhibits antimicrobial activity, inhibits the chlamydial inclusions with an IIC50 (the concentration to induce 50% inclusion inhibition) of 8.5 μg/mL[1].
UNSPSC
12352005
Target
Bacterial; Deubiquitinase
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/dub-in-8.html
Smiles
O=C(NCC1=CC=C(C(NC2[C@@H]3C[C@@H]4C[C@H]2C[C@@H](C4)C3)=O)C=C1)C5=CN=C(C#N)N=C5
Molecular Formula
C24H25N5O2
Molecular Weight
415.49
References & Citations
[1]Zimmermann T, et al., Structure-Based Design and Synthesis of Covalent Inhibitors for Deubiquitinase and Acetyltransferase ChlaDUB1 of Chlamydia trachomatis. J Med Chem. 2024 Jun 19.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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