Products for Research Use Only
RegisterLogin

A-740003

CAT: 0804-HY-50697-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-50697-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
A-740003 is a potent, selective and competitive P2X7 receptor antagonist with IC50 values are 18 and 40 nM for rat and human P2X7 receptors, respectively.
CAS Number
861393-28-4
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
P2X Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/a-740003.html
Purity
99.61
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
N#C/N=C(NC(NC(CC1=CC(OC)=C(C=C1)OC)=O)C(C)(C)C)\NC2=CC=CC3=NC=CC=C23
Molecular Formula
C26H30N6O3
Molecular Weight
474.55
Precautions
H302, H315, H319, H335
References & Citations
[1]Grol MW, et al. P2X?-mediated calcium influx triggers a sustained, PI3K-dependent increase in metabolic acid production by osteoblast-like cells. Am J Physiol Endocrinol Metab. 2012 Mar 1;302 (5) :E561-75.|[2]Kim JE, et al. P2X7 receptor activation ameliorates CA3 neuronal damage via a tumor necrosis factor-α-mediated pathway in the rat hippocampus following status epilepticus. J Neuroinflammation. 2011 Jun 2;8:62.|[3]Donnelly-Roberts DL, et al. Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors.Br J Pharmacol. 2009 Aug;157 (7) :1203-14. Epub 2009 Jun 22.|[4]Honore P, et al. A-740003 [N- (1-{[ (cyanoimino) (5-quinolinylamino) methyl]amino}-2,2-dimethylpropyl) -2- (3,4-dimethoxyphenyl) acetamide], a novel and selective P2X7 receptor antagonist, dose-dependently reduces neuropathic pain in the rat. J Pharmacol Exp Ther. 2006 Dec;319 (3) :1376-85. Epub 2006 Sep 18.|[5]Y. H. Gao, et al. Effect of electroacupuncture on the cervicospinal P2X7 receptor/fractalkine/CX3CR1 signaling pathway in a rat neck-incision pain model. Purinergic Signal. 2017 Jun;13 (2) :215-225.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P2X7 Receptor

Related Products

CatalogName
HY-125692L-740093
HY-10756BMS-740808
HY-118639-01CP-74006

Alternative Products

CatalogName
526702A-740003
sc-291774A 740003
A11316-100A 740003 100mg
A11316-50A 740003 50mg
A11316-25A 740003 25mg
A11316-10A 740003 10mg
A11316-5A 740003 5mg

Popular Products