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Celastramycin A (isomer)

CAT: 0804-HY-N12905-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N12905-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Celastramycin A isomer is an isomer of Celastramycin A , an antibiotic against Gram-negative bacteria and Mycobacterium tuberculosis with an MIC of 0.05-3.1 μg/mL. Celastramycin A exerts immunosuppressive effects in Drosophila ex vivo via the immunodeficiency pathway (IC50 of 8 ng/mL), inhibits human innate immune responses via the TNF-α pathway, and inhibits IL-8 production in HUEVC with an IC50 of 60 ng/mL[1][2].
CAS Number
491600-94-3
UNSPSC
12352005
Target
Antibiotic; Bacterial
Type
Natural Products
Related Pathways
Anti-infection
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/celastramycin-a-isomer.html
Smiles
O=C(C1=C(O)C(CCCCCC)=CC(Cl)=C1O)C2=CNC(Cl)=C2Cl
Molecular Formula
C17H18Cl3NO3
Molecular Weight
390.69
References & Citations
[1]Pullen C, et al., New and bioactive compounds from Streptomyces strains residing in the wood of Celastraceae. Planta. 2002 Nov;216 (1) :162-7. [Content Brief]|[2]Kikuchi H, et al., Revised structure and synthesis of celastramycin a, a potent innate immune suppressor. Org Lett. 2009 Apr 16;11 (8) :1693-5. [Content Brief]
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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