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Selfotel

CAT: 0804-HY-15086-02Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15086-02Size:10 mg
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Description
Selfotel (CGS 19755) is a selective and competitive antagonist at N-methyl-D-aspartate (NMDA) -preferring receptor. CGS 19755 inhibits the binding of [3H]-3- (2-carboxypiperazin-4-yl) propyl-1-phosphonic acid to NMDA-type receptors with an IC50 of 50 nM[1][2].
CAS Number
110347-85-8
Product Name Alternative
CGS 19755
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/selfotel.html
Purity
99.67
Solubility
H2O : 10 mg/mL (ultrasonic)
Smiles
O=C([C@@H]1NCC[C@H](CP(O)(O)=O)C1)O
Molecular Formula
C7H14NO5P
Molecular Weight
223.16
Precautions
H302, H315, H319, H335
References & Citations
[1]D A Bennett, et al. Behavioral pharmacological profile of CGS 19755, a competitive antagonist at N-methyl-D-aspartate receptors. J Pharmacol Exp Ther. 1989 Aug;250 (2) :454-60.|[2]J Lehmann, et al. CGS 19755, a selective and competitive N-methyl-D-aspartate-type excitatory amino acid receptor antagonist. J Pharmacol Exp Ther. 1988 Jul;246 (1) :65-75.|[3]M A Pérez-Pinzón, et al. Correlation of CGS 19755 neuroprotection against in vitro excitotoxicity and focal cerebral ischemia. J Cereb Blood Flow Metab. 1995 Sep;15 (5) :865-76.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3

Chemical Information

Selfotel

Selfotel is a non-proteinogenic alpha-amino acid.

CAS Number110347-85-8
PubChem CID68736
IUPAC Name(2S,4R)-4-(phosphonomethyl)piperidine-2-carboxylic acid
Molecular FormulaC7H14NO5P
Molecular Weight223.16
XLogP-3.9
Topological Polar Surface Area107
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Heavy Atom Count14
Formal Charge0
Complexity263
SMILES
C1CN[C@@H](C[C@@H]1CP(=O)(O)O)C(=O)O
InChI
InChI=1S/C7H14NO5P/c9-7(10)6-3-5(1-2-8-6)4-14(11,12)13/h5-6,8H,1-4H2,(H,9,10)(H2,11,12,13)/t5-,6+/m1/s1
InChIKey
LPMRCCNDNGONCD-RITPCOANSA-N
Chemical Structure
2D Structure
2D structure of Selfotel
CAS: 110347-85-8
CID: 68736
Formula: C7H14NO5P
MW: 223.16
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight223.16
XLogP3-3.9
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Exact Mass223.06095954
Monoisotopic Mass223.06095954
Topological Polar Surface Area107 Ų
Heavy Atom Count14
Formal Charge0
Complexity263
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
326895Selfotel

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