Suberic acid

• Description :

  Suberic acid (Octanedioic acid) is an orally active crystalline dibasic acid. Suberic acid activates the Akt signaling pathway and regulates the expression of molecules related to the TGF-β and MAPK signaling pathways. Suberic acid inhibits skin dryness[1][2].

• Product Name Alternative :

  Octanedioic acid

• UNSPSC :

  12352211

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Akt; Endogenous Metabolite; p38 MAPK; TGF-β Receptor

• Type :

  Natural Products

• Related Pathways :

  MAPK/ERK Pathway; Metabolic Enzyme/Protease; PI3K/Akt/mTOR; TGF-beta/Smad

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/Octanedioic_acid.html

• Purity :

  98.0

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  C(C(O)=O)CCCCCC(O)=O

• Molecular Formula :

  C8H14O4

• Molecular Weight :

  174.20

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Kang W, et al. Activation of OR10A3 by Suberic Acid Promotes Collagen Synthesis in UVB-Irradiated Dermal Fibroblasts via the cAMP-Akt Pathway. Cells. 2022 Dec 7;11 (24) :3961.|[2]Kang W, et al. Dietary Suberic Acid Protects Against UVB-Induced Skin Photoaging in Hairless Mice. Nutrients. 2019 Dec 4;11 (12) :2948.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  Human Endogenous Metabolite

• CAS Number :

  [505-48-6]