Mepenzolate (bromide)

CAT: 0804-HY-17585-01Size: 100 mgDry Ice: NoHazardous: No
CAT#:0804-HY-17585-01Size:100 mg
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Description
Mepenzolate bromide is an orally administered muscarinic receptor antagonist with Kis of 0.68 and 2.6 nM for hM2R and hM3R, respectively. Mepenzolate bromide can be used to suppress the gastrointestinal hypermotility associated with irritable bowel syndrome[1].Mepenzolate bromide is a GPR109A inhibitor[2].
CAS Number
[76-90-4]
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
GPR109A; mAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Inflammation/Immunology; Others
Assay Protocol
https://www.medchemexpress.com/Mepenzolate-Bromide.html
Concentration
10mM
Purity
99.90
Solubility
DMSO : 250 mg/mL (ultrasonic) |H2O : 10 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
C[N+]1(C)CC(OC(C(C2=CC=CC=C2)(O)C3=CC=CC=C3)=O)CCC1.[Br-]
Molecular Formula
C21H26BrNO3
Molecular Weight
420.34
Precautions
H302, H312, H332
References & Citations
[1]Yasunobu Yamashita, et al.Synthesis and biological comparison of enantiomers of mepenzolate bromide, a muscarinic receptor antagonist with bronchodilatory and anti-inflammatory activities. Bioorg Med Chem. 2014 Jul 1;22 (13) :3488-97.|[2]Hesham Aly Salem, et al. Effect of Niacin on Inflammation and Angiogenesis in a Murine Model of Ulcerative Colitis. Sci Rep. 2017 Aug 2;7 (1) :7139.|[3]Ken-Ichiro Tanaka, et al. Mepenzolate bromide displays beneficial effects in a mouse model of chronic obstructive pulmonary disease. Nat Commun. 2013;4:2686.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched

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