Octreotide (acetate)

• Description :

  Octreotide acetate, a long-acting synthetic analog of native somatostatin, inhibits growth hormone, glucagon, and insulin more potently.

• Product Name Alternative :

  SMS 201-995 (acetate)

• UNSPSC :

  12352209

• Hazard Statement :

  H315, H319

• Target :

  Somatostatin Receptor

• Type :

  Peptides

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology; Cardiovascular Disease; Endocrinology; Cancer

• Assay Protocol :

  https://www.medchemexpress.com/Octreotide-acetate.html

• Purity :

  99.97

• Solubility :

  DMSO : 100 mg/mL (ultrasonic) |H2O : 25 mg/mL (ultrasonic)

• Smiles :

  O=C([C@@H](NC([C@H](CSSC[C@H](NC([C@](NC([C@@H](NC1=O)CCCCN)=O)([H])[C@H](O)C)=O)C(N[C@H](CO)[C@H](O)C)=O)NC([C@H](N)CC2=CC=CC=C2)=O)=O)CC3=CC=CC=C3)N[C@@H]1CC4=CNC5=CC=CC=C45.CC(O)=O

• Molecular Formula :

  C51H70N10O12S2

• Molecular Weight :

  1079.29

• Precautions :

  H315, H319

• References & Citations :

  [1]Wang M, et al. Pharmacokinetic and pharmacodynamic study of a phospholipid-based phase separation gel for once a month administration of octreotide. J Control Release. 2016 May 28;230:45-56.|[2]Kim S, et al. Treatment of Gastrin-Secreting Tumor With Sustained-Release Octreotide Acetate in a Dog. J Am Anim Hosp Assoc. 2015 Nov-Dec;51 (6) :407-12.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)

• Scientific Category :

  Peptides

• Clinical Information :

  Launched

• Citation 01 :

  J Biol Chem. 2025 Jul 30;301 (9) :110544.|Mol Med Rep. 2024 Jun;29 (6) :90.|Nat Commun. 2023 Feb 21;14 (1) :962.|Patent. US20240307504A1.|Research Square Print. 2022 Aug.|Basic Clin Pharmacol Toxicol. 2022 Sep;131 (3) :174-188.|Biomacromolecules. 2024 May 13;25 (5) :2749-2761.|Cell Mol Bioeng. 2022 Dec 22;16 (1) :55-67.|Eur J Nucl Med Mol Imaging. 2024 Nov;51 (13) :4099-4110.|Faculty of Biological and Environmental Sciences. University of Helsinki Finland. 2018 Dec.|J Pharm Biomed Anal. 2022 Mar 20:211:114518.|J Pharm Biomed Anal. 2023 Feb 5:224:115156.|J Pharm Sci. 2022 Dec;111 (12) :3417-3423.|Mol Cancer. 2024 Sep 20;23 (1) :205.

• CAS Number :

  [79517-01-4]