Octreotide (acetate)

• Description:

  Octreotide acetate, a long-acting synthetic analog of native somatostatin, inhibits growth hormone, glucagon, and insulin more potently.

• Product Name Alternative:

  SMS 201-995 (acetate)

• UNSPSC:

  12352209

• Hazard Statement:

  H315, H319

• Target:

  Somatostatin Receptor

• Type:

  Peptides

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology; Cardiovascular Disease; Endocrinology; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Octreotide-acetate.html

• Purity:

  99.97

• Solubility:

  DMSO : 100 mg/mL (ultrasonic) |H2O : 25 mg/mL (ultrasonic)

• Smiles:

  O=C ([C@@H] (NC ([C@H] (CSSC[C@H] (NC ([C@] (NC ([C@@H] (NC1=O) CCCCN) =O) ([H]) [C@H] (O) C) =O) C (N[C@H] (CO) [C@H] (O) C) =O) NC ([C@H] (N) CC2=CC=CC=C2) =O) =O) CC3=CC=CC=C3) N[C@@H]1CC4=CNC5=CC=CC=C45.CC (O) =O

• Molecular Formula:

  C51H70N10O12S2

• Molecular Weight:

  1079.29

• Precautions:

  H315, H319

• References & Citations:

  [1]Wang M, et al. Pharmacokinetic and pharmacodynamic study of a phospholipid-based phase separation gel for once a month administration of octreotide. J Control Release. 2016 May 28;230:45-56.|[2]Kim S, et al. Treatment of Gastrin-Secreting Tumor With Sustained-Release Octreotide Acetate in a Dog. J Am Anim Hosp Assoc. 2015 Nov-Dec;51 (6) :407-12.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)

• Scientific Category:

  Peptides

• Clinical Information:

  Launched

• Citation 01:

  J Biol Chem. 2025 Jul 30;301 (9) :110544.|Mol Med Rep. 2024 Jun;29 (6) :90.|Nat Commun. 2023 Feb 21;14 (1) :962.|Patent. US20240307504A1.|Research Square Print. 2022 Aug.|Basic Clin Pharmacol Toxicol. 2022 Sep;131 (3) :174-188.|Biomacromolecules. 2024 May 13;25 (5) :2749-2761.|Cell Mol Bioeng. 2022 Dec 22;16 (1) :55-67.|Eur J Nucl Med Mol Imaging. 2024 Nov;51 (13) :4099-4110.|Faculty of Biological and Environmental Sciences. University of Helsinki Finland. 2018 Dec.|J Pharm Biomed Anal. 2022 Mar 20:211:114518.|J Pharm Biomed Anal. 2023 Feb 5:224:115156.|J Pharm Sci. 2022 Dec;111 (12) :3417-3423.|Mol Cancer. 2024 Sep 20;23 (1) :205.

• CAS Number:

  79517-01-4