Octreotide-d8

CAT: 0804-HY-P0036S2Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-P0036S2Size:1 Each
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Description
Octreotide-d8 (SMS 201-995-d8) is deuterium labeled Octreotide. Octreotide (SMS 201-995) is a somatostatin receptor agonist and synthetic octapeptide endogenous somatostatin analogue. Octreotide (SMS 201-995) can bind to the somatostatin receptor and mainly subtypes 2, 3, and 5, increases Gi activity, and reduces intracellular cAMP production. Octreotide (SMS 201-995) has antitumor activity, mediates apoptosis and may also be used in disease studies in acromegaly[1][2].
CAS Number
[1240797-41-4]
Product Name Alternative
SMS 201-995-d8
UNSPSC
12352005
Target
Apoptosis; Isotope-Labeled Compounds; Somatostatin Receptor
Related Pathways
Apoptosis; GPCR/G Protein; Neuronal Signaling; Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Endocrinology; Inflammation/Immunology; Cardiovascular Disease
Smiles
O=C([C@@H](NC([C@@H](CSSC[C@H](NC([C@](NC([C@@H](NC1=O)CCCCN)=O)([H])[C@H](O)C)=O)C(NC(CO)C(O)C)=O)NC(C(N)([2H])C([2H])([2H])C2=C([2H])C([2H])=C([2H])C([2H])=C2[2H])=O)=O)CC3=CC=CC=C3)N[C@H]1CC4=CNC5=CC=CC=C45
Molecular Formula
C49H58D8N10O10S2
Molecular Weight
1027.29
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Xiao-Xia Wang, et al. Effects of octreotide on hepatic glycogenesis in rats with high fat diet‑induced obesity. Mol Med Rep. 2017 Jul;16 (1) :109-118.|[3]Wang XX, et al. Effects of octreotide on hepatic glycogenesis in rats with high fat diet?induced obesity. Mol Med Rep. 2017 Jul;16 (1) :109-118|[4]Kugita M, et al. Beneficial effect of combined treatment with octreotide and pasireotide in PCK rats, an orthologous model of human autosomal recessive polycystic kidney disease. PLoS One. 2017 May 18;12 (5) :e0177934.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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