Ursodeoxycholic acid (sodium)

• UNSPSC Description:

  Ursodeoxycholic acid (Ursodeoxycholate) sodium is a secondary bile acid issued from the transformation of (cheno)deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and essential for lipid metabolism. Ursodeoxycholic acid sodium acts as signaling molecule, exerting its effects by interacting with bile acid activated receptors, including G-protein coupled bile acid receptor 5 (TGR5, GPCR19) and the farnesoid X receptor (FXR). Ursodeoxycholic acid sodium can be used for the research of a variety of hepatic and gastrointestinal diseases. Orally active[1][2].

• Target Antigen:

  Endogenous Metabolite; FXR; G protein-coupled Bile Acid Receptor 1

• Type:

  Natural Products

• Related Pathways:

  GPCR/G Protein;Metabolic Enzyme/Protease

• Field of Research:

  Cancer; Metabolic Disease; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/ursodeoxycholic-acid-sodium.html

• Smiles:

  C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(O[Na])=O)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4([C@](C[C@@H](CC4)O)([H])C[C@@H]3O)C

• Molecular Weight:

  414.55

• References & Citations:

  [1]Winston JA, et al. Secondary bile acid ursodeoxycholic acid alters weight, the gut microbiota, and the bile acid pool in conventional mice. PLoS One. 2021;16(2):e0246161. Published 2021 Feb 18. |[2]Goossens JF, et al. Ursodeoxycholic acid and cancer: From chemoprevention to chemotherapy. Pharmacol Ther. 2019;203:107396. Biochim Biophys Acta Mol Basis Dis. 2024 Mar;1870(3):167029.|Aquaculture. 2024 Nov 15.|Cell Host Microbe. 2024 Feb 14;32(2):191-208.e9.|Cell Prolif. 2023 Apr 26.|Cells. 2022, 11(19), 2951.|Clin Neuropharmacol. 10.1097.|Free Radic Biol Med. 2020 May 20;152:821-837.|Int J Mol Sci. 2024 Jan 11, 25(2), 919.|Nat Commun. 2023 May 2;14(1):2523.|Nature. 2024 Dec 18.|Neurosci Lett. 2021 Jan 10;741:135493.|Phytomedicine. 2024 Sep:132:155886.|Research Square Preprint. 2021 Aug.

• Shipping Conditions:

  Room Temperature

• CAS Number:

  2898-95-5