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Methyl helicterate

CAT: 0804-HY-125522Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-125522Size:1 Each
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Description
Methyl helicterate is a triterpenoid, that can be isolated from Helicteres angustifolia (Sterculiaceae) . Methyl helicterate inhibits hepatic stellate cell activation and promotes cell apoptosis through downregulating the ERK1/2 signaling pathway[1][2][3].
CAS Number
102637-02-5
UNSPSC
12352005
Target
Apoptosis; ERK
Type
Natural Products
Related Pathways
Apoptosis; MAPK/ERK Pathway; Stem Cell/Wnt
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/methyl-helicterate.html
Smiles
CC1([C@H](CC[C@@]2([C@]3(CC[C@@]4([C@]5([C@@H](CC[C@@]5(CC[C@]4([C@@]3(CC[C@@]12[H])C)COC(C6=CC=CC=C6)=O)C(OC)=O)C(C)=C)[H])[H])[H])C)OC(C)=O)C
Molecular Formula
C40H56O6
Molecular Weight
632.87
References & Citations
[1]Wei Y, et al. Methyl helicterate inhibits hepatic stellate cell activation through downregulating the ERK1/2 signaling pathway. J Cell Biochem. 2019 Sep;120 (9) :14936-14945.|[2]Huang Q, et al. Effect and mechanism of methyl helicterate isolated from Helicteres angustifolia (Sterculiaceae) on hepatic fibrosis induced by carbon tetrachloride in rats. J Ethnopharmacol. 2012 Oct 11;143 (3) :889-95.|[3]Chen W, et al. Pregnane, coumarin and lupane derivatives and cytotoxic constituents from Helicteres angustifolia. Phytochemistry. 2006 May;67 (10) :1041-7.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
ERK1; ERK2

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