Methyl pyruvate

• Description:

  Methyl pyruvate is a methyl ester derivative of pyruvic acid. Methyl pyruvate induces insulin release and membrane depolarization. Methyl pyruvate rescues proteasome damage and nuclear localization of TdP-43 caused by overexpression of σ1RE102Q by enhancing ATP synthesis. Methyl pyruvate selectively protects normal lung fibroblasts from cell death induced by Irinotecan (HY-16562) . Methyl pyruvate promotes apoptosis and necrosis in cancer cells and downregulates angiogenesis and cell cycle pathways. Methyl pyruvate is an effective substrate for dihydrodihydrogen dehydrogenase.

• UNSPSC:

  12352211

• Hazard Statement:

  H225

• Target:

  Apoptosis; ATP Synthase

• Related Pathways:

  Apoptosis; Membrane Transporter/Ion Channel

• Field of Research:

  Cancer; Metabolic Disease

• Purity:

  99.91

• Solubility:

  DMSO : 200 mg/mL (ultrasonic)

• Smiles:

  O=C(OC)C(=O)C

• Molecular Formula:

  C4H6O3

• Molecular Weight:

  102.09

• Precautions:

  H225

• References & Citations:

  [1]Sato K, et al. Purification and characterization of dimeric dihydrodiol dehydrogenase from dog liver. J Biochem. 1994 Sep;116 (3) :711-7. |[2]Monchusi B, Ntwasa M. Methyl pyruvate protects a normal lung fibroblast cell line from irinotecan-induced cell death: Potential use as adjunctive to chemotherapy. PLoS One. 2017 Aug 10;12 (8) :e0182789.|[3]Tagashira H, et al. Methyl pyruvate rescues mitochondrial damage caused by SIGMAR1 mutation related to amyotrophic lateral sclerosis. Biochim Biophys Acta. 2014 Dec;1840 (12) :3320-34.|[4]Lembert N, et al. Methyl pyruvate initiates membrane depolarization and insulin release by metabolic factors other than ATP. Biochem J. 2001 Mar 1;354 (Pt 2) :345-50.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  Store at room temperature 3 years

• Scientific Category:

  Reference compound2

• Clinical Information:

  No Development Reported

• CAS Number:

  [600-22-6]