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Methyl pyruvate

CAT: 0804-HY-W012985-01Size: 10 gDry Ice: NoHazardous: No
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CAT#:0804-HY-W012985-01Size:10 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Methyl pyruvate is a methyl ester derivative of pyruvic acid. Methyl pyruvate induces insulin release and membrane depolarization. Methyl pyruvate rescues proteasome damage and nuclear localization of TdP-43 caused by overexpression of σ1RE102Q by enhancing ATP synthesis. Methyl pyruvate selectively protects normal lung fibroblasts from cell death induced by Irinotecan. Methyl pyruvate promotes apoptosis and necrosis in cancer cells and downregulates angiogenesis and cell cycle pathways. Methyl pyruvate is an effective substrate for dihydrodihydrogen dehydrogenase.
CAS Number
600-22-6
UNSPSC
12352211
Hazard Statement
H225
Target
Apoptosis; ATP Synthase
Related Pathways
Apoptosis; Membrane Transporter/Ion Channel
Field of Research
Cancer; Metabolic Disease
Purity
99.91
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
O=C(OC)C(=O)C
Molecular Formula
C4H6O3
Molecular Weight
102.09
Precautions
H225
References & Citations
[1]Sato K, et al. Purification and characterization of dimeric dihydrodiol dehydrogenase from dog liver. J Biochem. 1994 Sep;116 (3) :711-7. |[2]Monchusi B, Ntwasa M. Methyl pyruvate protects a normal lung fibroblast cell line from irinotecan-induced cell death: Potential use as adjunctive to chemotherapy. PLoS One. 2017 Aug 10;12 (8) :e0182789.|[3]Tagashira H, et al. Methyl pyruvate rescues mitochondrial damage caused by SIGMAR1 mutation related to amyotrophic lateral sclerosis. Biochim Biophys Acta. 2014 Dec;1840 (12) :3320-34.|[4]Lembert N, et al. Methyl pyruvate initiates membrane depolarization and insulin release by metabolic factors other than ATP. Biochem J. 2001 Mar 1;354 (Pt 2) :345-50.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature 3 years
Scientific Category
Reference compound2
Clinical Information
No Development Reported

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