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Methyl pyruvate

CAT: 0804-HY-W012985-01Size: 10 gDry Ice: NoHazardous: No
CAT#:0804-HY-W012985-01Size:10 g
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Description
Methyl pyruvate is a methyl ester derivative of pyruvic acid. Methyl pyruvate induces insulin release and membrane depolarization. Methyl pyruvate rescues proteasome damage and nuclear localization of TdP-43 caused by overexpression of σ1RE102Q by enhancing ATP synthesis. Methyl pyruvate selectively protects normal lung fibroblasts from cell death induced by Irinotecan (HY-16562) . Methyl pyruvate promotes apoptosis and necrosis in cancer cells and downregulates angiogenesis and cell cycle pathways. Methyl pyruvate is an effective substrate for dihydrodihydrogen dehydrogenase.
CAS Number
[600-22-6]
UNSPSC
12352211
Hazard Statement
H225
Target
Apoptosis; ATP Synthase
Related Pathways
Apoptosis; Membrane Transporter/Ion Channel
Field of Research
Cancer; Metabolic Disease
Purity
99.91
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
O=C(OC)C(=O)C
Molecular Formula
C4H6O3
Molecular Weight
102.09
Precautions
H225
References & Citations
[1]Sato K, et al. Purification and characterization of dimeric dihydrodiol dehydrogenase from dog liver. J Biochem. 1994 Sep;116 (3) :711-7. |[2]Monchusi B, Ntwasa M. Methyl pyruvate protects a normal lung fibroblast cell line from irinotecan-induced cell death: Potential use as adjunctive to chemotherapy. PLoS One. 2017 Aug 10;12 (8) :e0182789.|[3]Tagashira H, et al. Methyl pyruvate rescues mitochondrial damage caused by SIGMAR1 mutation related to amyotrophic lateral sclerosis. Biochim Biophys Acta. 2014 Dec;1840 (12) :3320-34.|[4]Lembert N, et al. Methyl pyruvate initiates membrane depolarization and insulin release by metabolic factors other than ATP. Biochem J. 2001 Mar 1;354 (Pt 2) :345-50.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature 3 years
Scientific Category
Reference compound2
Clinical Information
No Development Reported

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