DBCO-PEG2-NHS ester

DBCO-PEG2-NHS ester

• CAS Number: 2585653-12-7
• UNSPSC Description: DBCO-PEG2-NHS ester is a click chemistry reagent containing an azide group. DBCO-PEG2-NHS ester is a click chemistry PEG reagent containing NHS ester that is able to react specifically and efficiently with primary amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic condition to form a covalent bond. The hydrophilic PEG spacer arm improves water solubility and provides a long and flexible connection that minimizes steric hindrance involved with ligation. DBCO is commonly used for copper-free Click Chemistry reactions. Reagent grade, for research use only[1].
• Target Antigen: ADC Linker
• Type: Reference compound
• Related Pathways: Antibody-drug Conjugate/ADC Related
• Applications: Cancer-programmed cell death
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/dbco-peg2-nhs-ester.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(CCOCCOCCNC(CCC(N1C2=C(C#CC3=C(C1)C=CC=C3)C=CC=C2)=O)=O)ON4C(CCC4=O)=O
• Molecular Weight: 561.58
• References & Citations: [1]Jiang X, et al. Recent applications of click chemistry in drug discovery. Expert Opin Drug Discov. 2019 Aug;14(8):779-789.
• Shipping Conditions: Blue Ice
• Clinical Information: No Development Reported