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Danshensu (sodium)

CAT: 0804-HY-N1913A-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N1913A-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Danshensu (Dan shen suan A) sodium, an orally active phenolic compound, can induce Nrf2/HO-1 activation and inhibition of NF-κB pathway. Danshensu sodium reduces reactive oxygen species (ROS) production, upregulates antioxidant defense mechanism and inhibits intrinsic apoptotic pathway. Danshensu sodium displays a potent antiviral activity against SARS-CoV-2 with EC50 of 0.97 μM. Danshensu sodium has anti-oxidation, anti-apoptosis, anti-lung inflammatory and has the potential for COVID-19, cardiovascular and cerebrovascular diseases research[1][2][3].
CAS Number
81075-52-7
Product Name Alternative
Dan shen suan A (sodium) ; Salvianic acid A (sodium)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Keap1-Nrf2; NF-κB; Reactive Oxygen Species (ROS) ; SARS-CoV
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection; Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/danshensu-sodium.html
Purity
99.9
Solubility
H2O : 50 mg/mL (ultrasonic)
Smiles
O=C(O[Na])[C@H](O)CC1=CC(O)=C(C=C1)O
Molecular Formula
C9H9NaO5
Molecular Weight
220.15
Precautions
H302, H315, H319, H335
References & Citations
[1]Wei Wang, et al. Danshensu alleviates pseudo-typed SARS-CoV-2 induced mouse acute lung inflammation. Acta Pharmacol Sin. 2022 Apr;43 (4) :771-780. |[2]V Bharath Kumar, et al. Sodium Danshensu Inhibits Oral Cancer Cell Migration and Invasion by Modulating p38 Signaling Pathway. Front Endocrinol (Lausanne) . 2020 Sep 30:11:568436. |[3]Chen Yu, et al. Danshensu attenuates cisplatin-induced nephrotoxicity through activation of Nrf2 pathway and inhibition of NF-κB. Biomed Pharmacother. 2021 Oct:142:111995.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Citation 01
Eur J Pharmacol. 2025 Feb 1:177296.|Breast Cancer Res Treat. 2024 Dec;208 (3) :657-671.|Cancer Immunol Immunother. 2025 Jun 30;74 (8) :256.|J Tradit Complement Med. 2025 Feb 7;15 (4) :434-445.|Phytomedicine. 2023 May:113:154743.

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