Big Endothelin-1 (Human, 1-38)

• Description:

  Big Endothelin-1 (Human, 1-38) Catalog number: MDP0598 CAS Number: 167699-60-7 Sequence: Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-His-Val-Val-Pro-Tyr-Gly-Leu-Gly-Ser-Pro-Arg-Ser (Disulfide bonds between Cys1-Cys15 and Cys3-Cys11) Amount: 500 ug Molecular Weight: 4282.8 g/mol Supplied as: Powder Applications: molecular tool for various biochemical applications Storage: -20 °C WARNING: For in vitro Research Use Only. NOT for use on humans or animals. Grade: Biotechnology grade. All products are highly pure. References: 1: Gratton JP, Rae GA, Claing A, Télémaque S, D'Orléans-Juste P. Different pressor and bronchoconstrictor properties of human big-endothelin-1, 2 (1-38) and 3 in ketamine/xylazine-anaesthetized guinea-pigs Br J Pharmacol. 1995 Feb;114(3):720-6. 2: Hemsén A, Ahlborg G, Ottosson-Seeberger A, Lundberg JM. Metabolism of Big endothelin-1 (1-38) and (22-38) in the human circulation in relation to production of endothelin-1 (1-21) Regul Pept. 1995 Feb 14;55(3):287-97. 3: Okada K, Arai Y, Hata M, Matsuyama K, Yano M. Big endothelin-1 structure important for specific processing by endothelin-converting enzyme of bovine endothelial cells Eur J Biochem. 1993 Dec 1;218(2):493-8. 4: Hanson GC, Andersson KE, Gyllstedt E, Högestätt ED, Lindberg BF. Hydrolysis of big endothelin-1 by a serine protease in the membrane fraction of human lung Regul Pept. 1997 Jan 15;68(1):63-9. 5: Douglas SA, Robin Hiley C. Responses to endothelin-1, human proendothelin (1-38) and porcine proendothelin (1-39) in the rat on intravenous administration and in the blood perfused mesentery Neurochem Int. 1991;18(4):445-54. 6: Löffler BM, Jacot-Guillarmod H, Maire JP. Concentrations and ratios of immunoreactive big-endothelin-1 and endothelin-1 in human, rat and rabbit plasma Biochem Int. 1992 Aug;27(5):755-61. 7: Patel KV, Schrey MP. Human breast cancer cells contain a phosphoramidon-sensitive metalloproteinase which can process exogenous big endothelin-1 to endothelin-1: a proposed mitogen for human breast fibroblasts Br J Cancer. 1995 Mar;71(3):442-7. 8: Akabane S, Yoshimi H, Yoshida K, Kawano Y, Ashida T, Kinoshita O, Matsushima Y, Kawamura M, Imanishi M, Kuramochi M, et al. Differential effects of endothelin-1 and big endothelin on canine kidneys J Cardiovasc Pharmacol. 1991;17 Suppl 7:S302-4. 9: Leslie SJ, Johnston N, Strachan FE, Bagnall A, Gray GA, Newby DE, Denvir MA, Webb DJ. Endothelin-1-30 is not elevated in men with chronic heart failure J Cardiovasc Pharmacol. 2004 Nov;44 Suppl 1:S96-9. 10: Yorimitsu K, Shinmi O, Nishiyama M, Moroi K, Sugita Y, Saito T, Inagaki Y, Masaki T, Kimura S. Effect of phosphoramidon on big endothelin-2 conversion into endothelin-2 in human renal adenocarcinoma (ACHN) cells. Analysis of endothelin-2 biosynthetic pathway FEBS Lett. 1992 Dec 21;314(3):395-8.
  Products Related to Big Endothelin-1 (Human, 1-38) can be found at Peptides

• Short Description:

  Catalog Number: MDP0598 (500 ug)

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height:

  0.5

• Height :

  0.5