Products for Research Use Only
RegisterLogin

5A2-SC8

CAT: 0804-HY-145799-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-145799-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
5A2-SC8 is an ionizable amino lipid in lipid nanoparticles (LNPs) that shows high delivery potential and low in vivo toxicity, enabling efficient delivery of small RNAs such as siRNA and miRNA into tumor cells. 5A2-SC8 LNPs can confer a unique delivery fate of RNA within the liver, thereby changing the therapeutic outcomes in cancer models[1][2][3].
CAS Number
1857341-90-2
UNSPSC
12352211
Target
Liposome
Type
Oligonucleotides
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/5a2-sc8.html
Purity
99.89
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(CCN(CCNCCN(CCC(OCCOC(C(CSCCCCCCCC)C)=O)=O)CCC(OCCOC(C(CSCCCCCCCC)C)=O)=O)CCNCCN(CCC(OCCOC(C(CSCCCCCCCC)C)=O)=O)CCC(OCCOC(C(CSCCCCCCCC)C)=O)=O)OCCOC(C(CSCCCCCCCC)C)=O
Molecular Formula
C93H173N5O20S5
Molecular Weight
1841.72
References & Citations
[1]Zhou K, Nguyen LH, Miller JB, et al. Modular degradable dendrimers enable small RNAs to extend survival in an aggressive liver cancer model. Proc Natl Acad Sci U S A. 2016;113 (3) :520-525. |[2]Johnson, et al. "Lipid nanoparticle (LNP) chemistry can endow unique in vivo RNA delivery fates within the liver that alter therapeutic outcomes in a cancer model." Molecular pharmaceutics 19.11 (2022) : 3973-3986.|[3]Johnson, et al. The Impact of Lipid Nanoparticle Chemistry on RNA Delivery and Therapeutic Outcomes. Diss. 2022.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported
FAQ
What is 5A2-SC8? => 5A2-SC8 is an ionizable amino lipid used in lipid nanoparticle research, particularly for experimental delivery of RNA molecules such as siRNA, miRNA and mRNA. Its CAS number is 1857341-90-2. What is 5A2-SC8 used for? => 5A2-SC8 is primarily studied as a component of lipid nanoparticle RNA-delivery systems. Research applications include siRNA delivery, miRNA delivery, mRNA delivery, gene silencing, liver-targeted RNA delivery and experimental cancer research. Is 5A2-SC8 an ionizable lipid? => Yes. 5A2-SC8 is described in the scientific literature as an ionizable amino lipid used to formulate lipid nanoparticles for RNA delivery. Can 5A2-SC8 be used for siRNA delivery? => Yes, for research purposes. Published studies have used 5A2-SC8 nanoparticles for functional siRNA delivery, including delivery to hepatocytes and tumor cells in experimental liver models. Can 5A2-SC8 deliver miRNA? => Published research has investigated 5A2-SC8 nanoparticles for delivery of a let-7g miRNA mimic in an experimental liver cancer model. Has 5A2-SC8 been studied for mRNA delivery? => Yes. Published research describing the 5A2-SC8 LNP platform reports its use for delivery of siRNA, miRNA and mRNA to the liver in experimental systems. What is the CAS number of 5A2-SC8? => The CAS number of 5A2-SC8 is 1857341-90-2. Its molecular formula is C93H173N5O20S5. What is the molecular weight of 5A2-SC8? => 5A2-SC8 has a molecular weight of approximately 1841.7 g/mol. Is 5A2-SC8 intended for clinical use? => The Gentaur product is positioned as a research product, and the existing page reports no clinical development. It should therefore be presented as For Research Use Only (RUO) rather than as an approved therapeutic product.

Related Products

CatalogName
HY-148559-014A3-SC8
HY-173427K-5a2

Alternative Products

CatalogName
BA7864-15A2-SC8
TCL-01070-015A2-SC8 TFA
TRC-A104493-100MG4A3-SC8
MBS8535012-01eIF-5A2
sc-53468XPA (5A2)
GTR19209834-01K-5a2
sc-130556PCDHGC (5A2)
326807-01Olfactory Receptor 5A2
AMM05164GMonoclonal GOK / STIM1 Antibody (clone 5A2), Clone: 5A2
E8RT1202EIF-5A2 Antibody

Popular Products