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Hydroxy-PEG1-CH2-Boc

CAT: 0804-HY-141208-02Size: 1 gDry Ice: NoHazardous: No
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CAT#:0804-HY-141208-02Size:1 g
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Description
Hydroxy-PEG1-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
CAS Number
287174-32-7
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
PROTAC Linkers
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hydroxy-peg1-ch2-boc.html
Purity
99.49
Solubility
10 mM in DMSO
Smiles
O=C(OC(C)(C)C)COCCO
Molecular Formula
C8H16O4
Molecular Weight
176.21
Precautions
H302, H315, H319, H335
References & Citations
[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Alkyl/ether Linkers; PEG Linkers

Chemical Information

Hydroxy-PEG1-CH2CO2tBu
CAS Number287174-32-7
PubChem CID57802514
IUPAC Nametert-butyl 2-(2-hydroxyethoxy)acetate
Molecular FormulaC8H16O4
Molecular Weight176.21
XLogP0.3
Topological Polar Surface Area55.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Heavy Atom Count12
Formal Charge0
Complexity136
SMILES
CC(C)(C)OC(=O)COCCO
InChI
InChI=1S/C8H16O4/c1-8(2,3)12-7(10)6-11-5-4-9/h9H,4-6H2,1-3H3
InChIKey
GIDDJWYPWOFCCS-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Hydroxy-PEG1-CH2CO2tBu
CAS: 287174-32-7
CID: 57802514
Formula: C8H16O4
MW: 176.21
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight176.21
XLogP30.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Exact Mass176.10485899
Monoisotopic Mass176.10485899
Topological Polar Surface Area55.8 Ų
Heavy Atom Count12
Formal Charge0
Complexity136
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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