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DL-O-Phosphoserine

CAT: 0804-HY-15130-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0804-HY-15130-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DL-O-Phosphoserine is a normal metabolite in human biofluids and is a mixture of phosphoserine with two stereochemical structures (D-type and L-type O-phospho-serine) . O-phospho-L-serine is a competitive inhibitor of serine racemase and phagocytosis. O-phospho-L-serine inhibits the enzymatic reaction by competing with the active site of serine racemase, thereby affecting the production of D-serine. O-phospho-L-serine also mimics the phosphatidylserine head group, binds to the phosphatidylserine receptor, interferes with phagocytic signal transduction, and partially blocks the phagocytosis of apoptotic cells by cells. O-phospho-L-serin can be used in the research of retinal regeneration, bone repair, and insect growth and development[1][2].
CAS Number
17885-08-4
UNSPSC
12352211
Hazard Statement
H315, H319, H335
Target
Endogenous Metabolite
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/Serophen.html
Concentration
10mM
Purity
98.63
Solubility
H2O : 11.67 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
OP(OCC(C(O)=O)N)(O)=O
Molecular Formula
C3H8NO6P
Molecular Weight
185.07
Precautions
H315, H319, H335
References & Citations
[1]Bailey TJ, et al. The inhibitor of phagocytosis, O-phospho-L-serine, suppresses Müller glia proliferation and cone cell regeneration in the light-damaged zebrafish retina. Exp Eye Res. 2010 Nov;91 (5) :601-12.|[2]Mai R, Lux R, Proff P, Lauer G, Pradel W, Leonhardt H, Reinstorf A, Gelinsky M, Jung R, Eckelt U, Gedrange T, Stadlinger B. O-phospho-L-serine: a modulator of bone healing in calcium-phosphate cements. Biomed Tech (Berl) . 2008 Oct;53 (5) :229-33.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite

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Alternative Products

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T5057-01DL-O-Phosphoserine
TRC-P361200-100MGL-O-Phosphoserine
131998PSPH (Phosphoserine Phosphatase, L-3-phosphoserine Phosphatase, O-phosphoserine Phosphohydrolase)
164694L-O-Phosphoserine-13C315N
TRC-P361203-1MGL-O-Phosphoserine-13C3
131997-FITCPSPH (Phosphoserine Phosphatase, L-3-phosphoserine Phosphatase, O-phosphoserine Phosphohydrolase) (FITC)
131997-BiotinPSPH (Phosphoserine Phosphatase, L-3-phosphoserine Phosphatase, O-phosphoserine Phosphohydrolase) (Biotin)
MBS6391235-01PSPH (Phosphoserine Phosphatase, L-3-phosphoserine Phosphatase, O-phosphoserine Phosphohydrolase) (HRP)
369607Phosphoserine Phosphatase (PSPH, PSP, L-3-phosphoserine Phosphatase, O-phosphoserine Phosphohydrolase)
MBS6391232-01PSPH (Phosphoserine Phosphatase, L-3-phosphoserine Phosphatase, O-phosphoserine Phosphohydrolase) APC

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