FL442

CAT: 0804-HY-164477Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-164477Size:1 Each

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Description

FL442 is an Androgen Receptor (AR) modulator. FL442 exhibits strong inhibitory effects in AR-dependent prostate cancer cells, showing similar inhibitory efficiency to traditional antiandrogen drugs Bicalutamide and Enzalutamide (HY-70002), while maintaining antiandrogenic activity against the AR mutant F876L, which is highly resistant to Enzalutamide. Pharmacokinetic studies of FL442 in mice reveal a long half-life (8 hours), good targeting (prostate tissue), and metabolic stability, and it effectively inhibits LNCaP tumor growth at low plasma concentrations (30 ng/mL).

CAS Number

1431166-12-9

UNSPSC

12352005

Target

Androgen Receptor

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/fl442.html

Smiles

N#CC1=C(C(F)(F)F)C=C(C2=NOC3CCCCC23)C=C1

Molecular Formula

C15H13F3N2O

Molecular Weight

294.27

References & Citations

[1]Poutiainen PK, et al. Preclinical pharmacology of FL442, a novel nonsteroidal androgen receptor modulator. Mol Cell Endocrinol. 2014 Apr 25;387 (1-2) :8-18.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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GTR19239227-01	FL442

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