Products for Research Use Only
RegisterLogin

FL442

CAT: 0931-T200138-01Size: 25 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0931-T200138-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
1431166-12-9
Target
Androgen Receptor
Related Pathways
Endocrinology/Hormones
Bioactivity
FL442 is an Androgen Receptor (AR) modulator. This compound exhibits potent inhibitory effects in AR-dependent prostate cancer cells, showing similar suppression efficiency to the traditional antiandrogen drugs Bicalutamide and Enzalutamide. It also maintains antiandrogen activity against the Enzalutamide-resistant AR mutant F876L. The pharmacokinetic properties of FL442 in mice reveal a longer half-life (8 hours), excellent targeting (prostate tissue), and metabolic stability. Additionally, it is effective at inhibiting LNCaP tumor growth at low plasma concentrations (30 ng/mL) .
Smiles
N#CC=1C=CC(=CC1C(F)(F)F)C2=NOC3CCCCC23
Molecular Formula
C15H13F3N2O
Molecular Weight
294.27
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
GTR19239227-01FL442

Popular Products