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Recombinant Human Osteoprotegerin

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Background
Osteoprotegerin (OPG), also named osteoclastogenesis inhibitory factor (OCIF), and tumor necrosis factor receptor superfamily member 11B (TNFRSF11B), is a TNFRSF11B-encoded protein in humans. OPG is a 401 a.a. basic glycoprotein which comprises 7 structural domains. It is either a 60 kDa monomer or a 120 kDa dimer linked by disulfide bridges. OPG acts as a decoy receptor for the receptor activator of nuclear factor kappa B ligand (RANKL) and inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro and may also play a role in preventing arterial calcification. OPG has been applied to decrease bone resorption in women with postmenopausal osteoporosis and in patients with lytic bone metastases. Mature human OPG shares 86 %, 87 %, 92 %, 92 % and 88 % amino acid sequence identity with mouse, rat, equine, canine and bovine OPG, respectively.
Product Name Alternative
TNFRSF11B, Osteoclastogenesis Inhibitory Factor, Tumor Necrosis Factor Receptor Superfamily Member 11B
Gene ID
4982
UniProt
O00300
Target
ETFPPKYLHY DEETSHQLLC DKCPPGTYLK QHCTAKWKTV CAPCPDHYYT DSWHTSDECL YCSPVCKELQ YVKQECNRTH NRVCECKEGR YLEIEFCLKH RSCPPGFGVV QAGTPERNTV CKRCPDGFFS NETSSKAPCR KHTNCSVFGL LLTQKGNATH DNICSGNSES TQK
Purification
> 95 % by SDS-PAGE and HPLC analyses.
Endotoxin
Less than 1 EU/ug of rHuOPG as determined by LAL method.
Bioactivity
5
Storage Conditions
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.- 12 months from date of receipt, -20 to -70 °C as supplied.- 1 month, 2 to 8 °C under sterile conditions after reconstitution.- 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Calculated Molecular Weight
Approximately 19.7 kDa, a single non-glycosylated polypeptide chain containing 173 amino acids.
Formulation
Lyophilized from a 0.2 um filtered concentrated solution in PBS.
Host or Source
Escherichia coli

UniProtKB · O00300

Tumor necrosis factor receptor superfamily member 11B

TR11B_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O00300
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TNFRSF11B
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
B2R9A8, O60236, Q53FX6, Q9UHP4
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Biological process

Apoptosis

Disease

Disease variant

PTM

Disulfide bondGlycoprotein

Molecular function

Receptor

Domain

RepeatSignal

Cellular component

Secreted

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