Rat TNF alpha Recombinant Rabbit Monoclonal Antibody [PSH04-70] - BSA and Azide free (Capture)

• Description:

  Tumor necrosis factor (TNF, cachexin, or cachectin; formerly known as tumor necrosis factor alpha or TNF-α) is an adipokine and a cytokine. TNF is a member of the TNF superfamily, which consists of various transmembrane proteins with a homologous TNF domain. As an adipokine, TNF promotes insulin resistance, and is associated with obesity-induced type 2 diabetes. As a cytokine, TNF is used by the immune system for cell signaling. If macrophages (certain white blood cells) detect an infection, they release TNF to alert other immune system cells as part of an inflammatory response. TNF signaling occurs through two receptors: TNFR1 and TNFR2. TNFR1 is constituitively expressed on most cell types, whereas TNFR2 is restricted primarily to endothelial, epithelial, and subsets of immune cells. TNFR1 signaling tends to be pro-inflammatory and apoptotic, whereas TNFR2 signaling is anti-inflammatory and promotes cell proliferation. Suppression of TNFR1 signaling has been important for treatment of autoimmune diseases, whereas TNFR2 signaling promotes wound healing.

• Product Name Alternative:

  APC1 antibody APC1 protein antibody Cachectin antibody DIF antibody Differentiation inducing factor antibody Macrophage cytotoxic factor antibody Tnf antibody TNF superfamily member 2 antibody TNF superfamily, member 2 antibody TNF, macrophage derived antibody TNF, monocyte derived antibody TNF-a antibody TNF-alpha antibody TNFA antibody TNFA_HUMAN antibody TNFSF2 antibody Tumor necrosis factor (TNF superfamily member 2) antibody Tumor necrosis factor alpha antibody Tumor necrosis factor antibody Tumor necrosis factor ligand superfamily member 2 antibody Tumor Necrosis Factor, Membrane Form antibody Tumor necrosis factor, soluble form antibody

• Abbreviation:

  Tumor necrosis factor Cachectin TNF-alpha Tumor necrosis factor ligand superfamily member 2 (TNF-a) Tumor necrosis factor, membrane form N-terminal fragment (NTF) Intracellular domain 1 (ICD1) Intracellular domain 2 (ICD2) C-domain 1 C-domain 2 Tumor necrosis factor, soluble form Tnf Tnfa Tnfsf2

• Swiss Prot:

  P16599 Rat

• Cellular Locus:

  Cell membrane; Secreted.

• Host:

  Rabbit

• Species Reactivity:

  Rat

• Immunogen:

  Recombinant protein within Rat TNF alpha aa 80-235 (P16599).

• Isotype:

  IgG

• Clone:

  PSH04-70

• Conjugation:

  Non-conjugated

• Type:

  Recombinant Rabbit monoclonal Antibody

• Applications:

  ELISA (Cap)

• Positive Control:

  Recombinant Rat TNF-α protein (HA210538).

• Concentration:

  1 mg/mL

• Dilution:

  ELISA (Cap): Use at an assay dependent concentration. Can be paired for Sandwich ELISA with Rabbit monoclonal [PSH04-71] to Rat TNF alpha (Detector) (HA722171) and recombinant standard Rat TNF alpha (HA210538). The reference range value is 12.3-3000 pg/ml.

• Purity:

  Protein A affinity purified.

• Form:

  Liquid

• Buffer:

  PBS (pH7.4).

• Molecular Weight:

  Predicted band size: 26 kDa

• Storage Conditions:

  Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

• Recombinant Antibody:

  Yes

• CAS Number:

  9000-83-3