TACA

CAT: 0804-HY-100800-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-100800-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
TACA (trans-4-Aminocrotonic acid) is a potent agonist of GABAA and GABAC receptors (KD= 0.6 μM) . TACA also is GABA uptake inhibitor and substrate for GABA-T. TACA produces late biphasic responses in the MPG neurons[1][2][3].
CAS Number
[38090-53-8]
Product Name Alternative
Trans-4-Aminocrotonic acid
UNSPSC
12352211
Hazard Statement
H301-H311-H331-H341
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/taca.html
Concentration
10mM
Purity
99.33
Solubility
DMSO : < 1 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 20 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(O)/C=C/CN
Molecular Formula
C4H7NO2
Molecular Weight
101.10
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P403+P233-P405-P501
References & Citations
[1]Chebib M, et al. Analogues of gamma-aminobutyric acid (GABA) and trans-4-aminocrotonic acid (TACA) substituted in the 2 position as GABAC receptor antagonists. Br J Pharmacol. 1997;122 (8) :1551-1560.|[2]Akasu T, et al. Role of GABAA and GABAC receptors in the biphasic GABA responses in neurons of the rat major pelvic ganglia. J Neurophysiol. 1999;82 (3) :1489-1496.|[3]Johnston GA, et al. Cis- and trans-4-aminocrotonic acid as GABA analogues of restricted conformation. J Neurochem. 1975;24 (1) :157-160.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-146346-01HD-TAC7
HY-P71128-01TAC1, Human (His)
HY-180376TAC 363
HY-P83814-01TACI Antibody (YA3511, Mouse)
HY-P83815-01TACI Antibody (YA3512, Mouse)
HY-P81640TACI Antibody (YA1385, Rabbit)
HY-P72815-01ADAM17/TACE, Rat (HEK293, His)
HY-P78717-01ADAM17/TACE, Mouse (HEK293, His)
HY-P7229-01I-TAC/CXCL11, Human
HY-P71886-01I-TAC/CXCL11, Mouse

Alternative Products

CatalogName
sc-203705TACA

Popular Products