Dopamine-d5 (hydrochloride)

Dopamine-d5 (hydrochloride)

• CAS Number: 2193106-55-5
• UNSPSC Description: Dopamine-d5 (hydrochloride) is the deuterium labeled Dopamine (hydrochloride). Dopamine hydrochloride (ASL279) is a catecholamine neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. Dopamine hydrochloride (ASL279) plays several important roles in the brain and body[1]. Dopamine hydrochloride (ASL279) acts through D2 dopamine receptors to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis[1].
• Target Antigen: Dopamine Receptor; Endogenous Metabolite; Ferroptosis; Isotope-Labeled Compounds
• Type: Isotope-Labeled Compounds
• Related Pathways: Apoptosis;GPCR/G Protein;Metabolic Enzyme/Protease;Neuronal Signaling;Others
• Applications: Neuroscience-Neurodegeneration
• Field of Research: Neurological Disease
• Purity: 99.6
• Solubility: H2O : 50 mg/mL (ultrasonic;warming)
• Smiles: NCC([2H])([2H])C1=C([2H])C(O)=C(C([2H])=C1[2H])O.Cl
• Molecular Weight: 194.67
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Juárez Olguín H, et al. The Role of Dopamine and Its Dysfunction as a Consequence of Oxidative Stress. Oxid Med Cell Longev. 2016;2016:9730467.|[3]Basu S, et al. The neurotransmitter dopamine inhibits angiogenesis induced by vascular permeability factor/vascular endothelial growth factor. Nat Med. 2001 May;7(5):569-74.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported