Dopamine (hydrochloride)

• UNSPSC Description:

  Dopamine hydrochloride (ASL279) is a catecholamine neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. Dopamine hydrochloride (ASL279) plays several important roles in the brain and body[1]. Dopamine hydrochloride (ASL279) acts through D2 dopamine receptors to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis[1].

• Target Antigen:

  Dopamine Receptor; Endogenous Metabolite; Ferroptosis

• Type:

  Natural Products

• Related Pathways:

  Apoptosis;GPCR/G Protein;Metabolic Enzyme/Protease;Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/Dopamine-hydrochloride.html

• Purity:

  99.61

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)|H2O : ≥ 50 mg/mL

• Smiles:

  OC1=CC=C(CCN)C=C1O.Cl

• Molecular Weight:

  189.64

• References & Citations:

  [1]Juárez Olguín H, et al. The Role of Dopamine and Its Dysfunction as a Consequence of Oxidative Stress. Oxid Med Cell Longev. 2016;2016:9730467.|[2]Basu S, et al. The neurotransmitter dopamine inhibits angiogenesis induced by vascular permeability factor/vascular endothelial growth factor. Nat Med. 2001 May;7(5):569-74.Biomed Pharmacother. 2019 Nov;119:109419.|Eur J Pharmacol. 2023 Nov 6:176174.|Int J Mol Sci. 2022, 23(20), 12420.|Int J Nanomedicine. 2024 Jul 3:19:6717-6730.|Nat Commun. 2024 Feb 6;15(1):1122.|New J Chem. 03 Aug 2022.|Phytother Res. 2023 Mar 8.|Sci Adv. 2023 Jun 2;9(22):eadg3365.|bioRxiv. 2023 Oct 13.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light, stored under nitrogen)

• Clinical Information:

  Launched

• CAS Number:

  62-31-7