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(-) -Limonene

CAT: 0804-HY-Z0478-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-Z0478-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(-) -Limonene ((S) - (-) -Limonene) is orally active and can cause mild bronchoconstriction. (-) -Limonene alleviates cytosolic and mitochondrial oxidative stress by inhibiting the increase of calcium ions (Ca2+) and Ca2+/calmodulin-dependent protein kinase II (CaMKII) . It also exerts anti-stress effects by inhibiting the activity of the hypothalamic-pituitary-adrenal (HPA) axis. Additionally, (-) -Limonene can be used as an antibacterial agent in aquaculture[1][2][3][4].
CAS Number
5989-54-8
Product Name Alternative
(S) - (-) -Limonene
UNSPSC
12352211
Hazard Statement
H226, H304, H317, H400
Target
Antibiotic; Bacterial; CaMK
Type
Natural Products
Related Pathways
Anti-infection; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Infection; Metabolic Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/_S_-_-_-Limonene.html
Purity
98.59
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)
Smiles
CC1=CC[C@@H](C(C)=C)CC1
Molecular Formula
C10H16
Molecular Weight
136.24
Precautions
H226, H304, H317, H400
References & Citations
[1]Larsen ST, et al. Effects of R- (+) - and S- (-) -limonene on the respiratory tract in mice. Hum Exp Toxicol. 2000 Aug;19 (8) :457-66.|[2]da Silva E G, et al. In vitro antimicrobial and antibiofilm activity of S- (-) -limonene and R- (+) -limonene against fish bacteria[J]. Fishes, 2021, 6 (3) : 32.|[3]Zhou W, et al. Sub-chronic effects of s-limonene on brain neurotransmitter levels and behavior of rats. J Nutr Sci Vitaminol (Tokyo) . 2009 Aug;55 (4) :367-73.|[4]Rhana P, et al. S-limonene protects the heart in an experimental model of myocardial infarction induced by isoproterenol: Possible involvement of mitochondrial reactive oxygen species. Eur J Pharmacol. 2022 Sep 5;930:175134.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
Launched
Isoform
CaMK II; Human Endogenous Metabolite

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