Limonin

• Description:

  Limonin inhibits HIV-1 with an EC50 of 60.0 μM. Limonin induces human colon adenocarcinoma cells apoptosis with an IC50 of 54.74 μM. Limonin has antiviral and antitumor activities[1][2][4].

• Product Name Alternative:

  Limonoic acid 3,19:16,17 dilactone

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319

• Target:

  Apoptosis; Cytochrome P450; Endogenous Metabolite; HIV; P-glycoprotein

• Type:

  Natural Products

• Related Pathways:

  Anti-infection; Apoptosis; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Infection; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Limonin.html

• Purity:

  99.38

• Solubility:

  DMSO : 41.67 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  O=C1[C@@H]2[C@@]3(O2)[C@](CC[C@@]([C@@]4([C@@](CC(OC4)=O)([H])OC5(C)C)[C@@]5([H])CC6=O)([H])[C@]36C)(C)[C@H](C7=COC=C7)O1

• Molecular Formula:

  C26H30O8

• Molecular Weight:

  470.51

• Precautions:

  H315, H319

• References & Citations:

  [1]Han YL, Yu HL, Li D, et al. Inhibitory effects of limonin on six human cytochrome P450 enzymes and P-glycoprotein in vitro. Toxicol In Vitro. 2011 Dec;25 (8) :1828-33.|[2]Kotamballi N. Chidambara Murthy, Jayaprakasha, Vinod Kumar, et al. Citrus Limonin and Its Glucoside Inhibit Colon Adenocarcinoma Cell Proliferation through Apoptosis. J. Agric. Food Chem., 2011, 59 (6) :2314-2323.|[3]Mahmoud Zaki El-Readi, Dalia Hamdana, Nawal Farrag, et al. Inhibition of P-glycoprotein activity by limonin and other secondary metabolites from Citrus species in human colon and leukaemia cell lines. European Journal of Pharmacology. 2010,626 (2-3) : 139-145.|[4]Battinelli L, Mengoni F, Lichtner M, et al. Effect of limonin and nomilin on HIV-1 replication on infected human mononuclear cells. Planta Med. 2003 Oct;69 (10) :910-3.|[5]Tanaka T, Kohno H, Tsukio Y, et al. Citrus limonoids obacunone and limonin inhibit azoxymethane-induced colon carcinogenesis in rats. Biofactors. 2000;13 (1-4) :213-8.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Isoform:

  HIV-1

• CAS Number:

  [1180-71-8]