Triptohypol C

• UNSPSC Description:

  Triptohypol C, a Tripterin (HY-13067) derivative, is a potent Nur77-targeting anti-inflammatory agent with an Kd value of 0.87 μM. Triptohypol C inhibits inflammatory response by promoting the interactions of Nur77 with TRAF2 and p62/SQSTM1[1].

• Target Antigen:

  Nuclear Hormone Receptor 4A/NR4A; p62

• Type:

  Natural Products

• Related Pathways:

  Autophagy;Vitamin D Related/Nuclear Receptor

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/triptohypol-c.html

• Purity:

  95.44

• Solubility:

  DMSO : 16.67 mg/mL (ultrasonic)

• Smiles:

  CC1=C(O)C(O)=CC2=C1CC=C3[C@@]2(C)CC[C@]4(C)[C@]3(C)CC[C@]5(C)[C@@]4([H])C[C@](C)(C(O)=O)CC5

• Molecular Weight:

  452.63

• References & Citations:

  [1]Chen Z, et al. SAR study of celastrol analogs targeting Nur77-mediated inflammatory pathway. Eur J Med Chem. 2019 Sep 1;177:171-187.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, protect from light)

• Clinical Information:

  No Development Reported

• CAS Number:

  193957-88-9