Azaserine

CAT: 0804-HY-B0919-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0919-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Azazerine (CI-337) is a competitive inhibitor of glutamine amidotransferase. Azaserine is an antibiotic, it shows antibacterial activities. Azazerine shows anti-tumor activities and it may also act as a tumor inducer. Azazerine can be used for the research of cancer and infection[1][2][3][4][5].
CAS Number
[115-02-6]
Product Name Alternative
CI-337; O-Diazoacetyl-L-serine; P-165
UNSPSC
12352211
Hazard Statement
H301, H351
Target
Antibiotic; Bacterial; DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/Azaserine.html
Purity
99.96
Solubility
H2O : 50 mg/mL (ultrasonic)
Smiles
N[C@@H](COC(C=[N+]=[N-])=O)C(O)=O
Molecular Formula
C5H7N3O4
Molecular Weight
173.13
Precautions
H301, H351
References & Citations
[1]Longnecker DS, Curphey TJ. Adenocarcinoma of the pancreas in azaserine-treated rats. Cancer Res. 1975 Aug;35 (8) :2249-58.|[2]Shigemichi GUNJI, et al. Screening of Antifungal Antibiotics According to Activities Inducing Morphological Abnormalities. Agric. Biol Chem., 47 (9), 2061-2069, 1983.|[3]Williams MV, Tritz GJ. Studies on the modes of action of azaserine inhibition of Escherichia coli. Potentiation of phenylalanine reversal. J Antimicrob Chemother. 1977 Jan;3 (1) :65-77.|[4]Catane R, et al. Azaserine, DON, and azotomycin: three diazo analogs of L-glutamine with clinical antitumor activity. Cancer Treat Rep. 1979 Jun;63 (6) :1033-8. |[5]Lyons SD, et al. Cytotoxic mechanisms of glutamine antagonists in mouse L1210 leukemia. J Biol Chem. 1990 Jul 5;265 (19) :11377-81.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-B1470-01Azaperone
HY-B1470SAzaperone-d4
HY-B1470R-01Azaperone (Standard)

Alternative Products

CatalogName
sc-29063Azaserine
A24139-5Azaserine 5mg
A24139-50Azaserine 50mg
A24139-10Azaserine 10mg
A24139-100Azaserine 100mg

Popular Products