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Thozalinone

CAT: 0804-HY-105856-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-105856-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Thozalinone is an orally active antidepressant agent. Thozalinone induces the release of Norepinephrine and dopamine[1][2].
CAS Number
655-05-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/thozalinone.html
Purity
99.93
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C1N=C(N(C)C)OC1C2=CC=CC=C2
Molecular Formula
C11H12N2O2
Molecular Weight
204.23
Precautions
H302, H315, H319, H335
References & Citations
[1]Greenblatt EN, et al. Some pharmacologic properties of thozalinone, a new excitant. Toxicol Appl Pharmacol. 1965 Jul;7 (4) :566-78. |[2]Yen-Koo HC, et al. Inhibition of dopaminergic agonist-induced gnawing behavior by neuroleptic drugs in mice. Drug Chem Toxicol. 1985;8 (6) :495-502.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Thozalinone
CAS Number655-05-0
PubChem CID12602
IUPAC Name2-(dimethylamino)-5-phenyl-1,3-oxazol-4-one
Molecular FormulaC11H12N2O2
Molecular Weight204.22
XLogP1.5
Topological Polar Surface Area41.9
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Heavy Atom Count15
Formal Charge0
Complexity280
SMILES
CN(C)C1=NC(=O)C(O1)C2=CC=CC=C2
InChI
InChI=1S/C11H12N2O2/c1-13(2)11-12-10(14)9(15-11)8-6-4-3-5-7-8/h3-7,9H,1-2H3
InChIKey
JJSHYECKYLDYAR-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Thozalinone
CAS: 655-05-0
CID: 12602
Formula: C11H12N2O2
MW: 204.22
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight204.22
XLogP31.5
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Exact Mass204.089877630
Monoisotopic Mass204.089877630
Topological Polar Surface Area41.9 Ų
Heavy Atom Count15
Formal Charge0
Complexity280
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
TRC-T398000-5MGThozalinone
467577Thozalinone-d5

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