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(-) -Hydroxycitric acid lactone

CAT: 0804-HY-N7347-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N7347-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(-) -Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a popular weight loss food supplement. (-) -Hydroxycitric acid lactone is a potent inhibitor of ATP-citrate lyase. (-) -Hydroxycitric acid lactone catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA, limits the availability of acetyl-CoA units required for fatty acid synthesis[1][2].
CAS Number
27750-13-6
Product Name Alternative
Garcinia lactone
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
ATP Citrate Lyase
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/minus-hydroxycitric-acid-lactone.html
Purity
99.82
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O[C@](CC(O1)=O)(C(O)=O)[C@H]1C(O)=O
Molecular Formula
C6H6O7
Molecular Weight
190.11
Precautions
H302, H315, H319, H335
References & Citations
[1]Han J, et al. (-) -Hydroxycitric acid reduced fat deposition via regulating lipid metabolism-related geneexpression in broiler chickens. Lipids Health Dis. 2016 Feb 24;15:37.|[2]Jena BS, et al. Chemistry and biochemistry of (-) -hydroxycitric acid from Garcinia. J Agric Food Chem. 2002 Jan 2;50 (1) :10-22.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Natural Products
Clinical Information
No Development Reported

Chemical Information

Hydroxycitric acid lactone

(+)-garcinia acid is a natural product found in Garcinia cambogia. It has a role as a metabolite. It is a butan-4-olide and a hydroxy carboxylic acid.

CAS Number27750-13-6
PubChem CID9991606
IUPAC Name(2S,3S)-3-hydroxy-5-oxooxolane-2,3-dicarboxylic acid
Molecular FormulaC6H6O7
Molecular Weight190.11
XLogP-1.2
Topological Polar Surface Area121
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count2
Heavy Atom Count13
Formal Charge0
Complexity283
SMILES
C1C(=O)O[C@@H]([C@@]1(C(=O)O)O)C(=O)O
InChI
InChI=1S/C6H6O7/c7-2-1-6(12,5(10)11)3(13-2)4(8)9/h3,12H,1H2,(H,8,9)(H,10,11)/t3-,6+/m1/s1
InChIKey
PFHZIWAVXDSFTB-CVYQJGLWSA-N
Chemical Structure
2D Structure
2D structure of Hydroxycitric acid lactone
CAS: 27750-13-6
CID: 9991606
Formula: C6H6O7
MW: 190.11
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight190.11
XLogP3-1.2
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count2
Exact Mass190.01135253
Monoisotopic Mass190.01135253
Topological Polar Surface Area121 Ų
Heavy Atom Count13
Formal Charge0
Complexity283
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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