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αO-Conotoxin GeXIVA

CAT: 0804-HY-P5848Size: InquireDry Ice: NoHazardous: No
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CAT#:0804-HY-P5848Size:Inquire
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CAS Number
2010167-25-4
UNSPSC Description
αO-Conotoxin GeXIVA is a potent α9α10 nAChR antagonist with an IC50 of 12 nM against rat α9α10. αO-Conotoxin GeXIVA shows analgesic in animal models of pain[1].
Target Antigen
nAChR
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Solubility
10 mM in DMSO
Smiles
O=C([C@@H](N)[C@@H](C)O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H]1CC2=CC=C(O)C=C2)=O)CCCNC(N)=N)=O)=O)CO)=O)CO)=O)CCCNC(N)=N)=O)CSSC[C@H](NC1=O)C(N[C@H](C(N[C@H](C(N3[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]4C)=O)CC(O)=O)=O)[C@@H](C)O)=O)[C@H](CC)C)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CSSC[C@H](NC4=O)C(N[C@H](C(O)=O)C(C)C)=O)=O)CC5=CC=C(O)C=C5)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CC(O)=O)=O)CC6=CC=C(O)C=C6)=O)CCC3)=O)CO)=O)CCCNC(N)=N)=O
Molecular Weight
3452.89
References & Citations
[1]Xu P, et al. Structure and Activity Studies of Disulfide-Deficient Analogues of αO-Conotoxin GeXIVA. J Med Chem. 2020 Feb 27;63(4):1564-1575.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported

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