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WYJ-2

CAT: 0804-HY-158058Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-158058Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
WYJ-2 is a selective agonist for toll-like receptor 2/1 (TLR2/1) with EC50 of 18.57 nM in human TLR2 and TLR1 transient-cotransfected HEK 293T cells. WYJ-2 induces pyroptosis and exhibits anticancer activity against non-small cell lung cancer (NSCLC) [1].
CAS Number
3029403-05-9
UNSPSC
12352005
Target
Pyroptosis; Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/wyj-2.html
Solubility
10 mM in DMSO
Smiles
FC1=CC=C(C=C1C2=NC(C3=CC4=CC(F)=CC=C4OC3)=NO2)[N+]([O-])=O
Molecular Formula
C17H9F2N3O4
Molecular Weight
357.27
References & Citations
[1]Wang Y, et al., Design and Synthesis of 3- (2H-Chromen-3-yl) -5-aryl-1,2,4-oxadiazole Derivatives as Novel Toll-like Receptor 2/1 Agonists That Inhibit Lung Cancer In Vitro and In Vivo. J Med Chem. 2024 Mar 18.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TLR2

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