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A-770041

CAT: 0804-HY-11011-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-11011-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A-770041 is a selective and orally active Src-family Lck inhibitor. A-770041 inhibits Lck with an IC50 value of 147 nM with the presence of 1 mM ATP. A-770041 shows 300-fold selective to Lck over Fyn, the other Src family kinase involved in T-cell signaling. A-770041 can be used for the research of acute rejection[1][2].
CAS Number
869748-10-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Src
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/a-770041.html
Purity
99.89
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
NC1=C2C(N([C@@H]3CC[C@@H](N4CCN(C(C)=O)CC4)CC3)N=C2C5=CC=C(NC(C6=CC7=C(C=CC=C7)N6C)=O)C(OC)=C5)=NC=N1
Molecular Formula
C34H39N9O3
Molecular Weight
621.73
Precautions
H302, H315, H319, H335
References & Citations
[1]Stachlewitz RF, et al.A-770041, a novel and selective small-molecule inhibitor of Lck, prevents heart allograft rejection.J Pharmacol Exp Ther. 2005 Oct;315 (1) :36-41.|[2]Andrew Burchat, et al. Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection Bioorganic & Medicinal Chemistry Letters Volume 16, Issue 1, 1 January 2006, Pages 118-122
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
UJB74810-01A-770041
A11288-100A-770041 100mg
A11288-50A-770041 50mg
A11288-25A-770041 25mg
A11288-1A-770041 1mg
A11288-200A-770041 200mg
A11288-10A-770041 10mg
A11288-5A-770041 5mg
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